Figured you knew about all this Dow...the calculators are a handy thing to do the math
I'd like to clarify one thing on quench...generally, a tight quench area is good, but only to the point where it does not impede the flame front across the combustion chamber. Increasing static compression will give you better lower end...at the same time you do not want detonation as a result. This is where the quench area comes in...it's like walking a tight rope. You're increasing static CR with either the Wisco or Arias pistons...when I said to increase the quench area slightly, it was relative to the static CR associated with these pistons. Your quench area will actually be smaller than stock if you use a slightly thicker MHG, considering the material removed from the block/head decks of course. As you said, the tune + valve timing will have a huge impact.
You're smart to focus on the bottom end...that's where the power goes

I never have understood why guys skimp on this part...sounds like to me you're going to cover that base quite well. If the MHG you choose doesn't meet expectations...you're right...changing it out is easy compared to having to tear down the bottom end again!