Maximum fuel mileage will be obtained with widest throttle opening and lower RPM, provided that the ECU remains in closed loop mode to keep the mixture stoiciometric. Specifically, when boost begins, the ECU is taken out of closed loop mixture control, and the mixture richens. The more an engine is throttled, the lower the efficiency. So, a 3.73 rear with a taller fifth gear should result in better fuel economy, but downshift going up grades if boost begins.