Gas mileage is directly attached to boost levels.
More boost, more fuel.
Also your state of tune really comes into play in how well your car runs. IF your running rich to save the motor and run more boost, your going to get crappy gas mileage. If your O2 is bad, same deal. Plugs, wires and other stuff that affects how well your engine runs also affects your gas mileage. (Misfires are just wasted fuel.)
On that note, last time I checked, with an extended run from Boise to Pocatello, I averaged 28mpg on cruise control at 82mph. (No boosting was done, or very minimal amounts.)
This was with idle vac clamped off to the AFPR, and showing 2.5v at the check connector. (Stock base fuel map.)
My mods at the time were a SS Stage V BB CHRA 60-1, 3" exhaust out, no cats, HKS catback, 550's and Lexus meter. Larger FMIC and hardpipes etc. Also had 275/50/17's on there at the time. (Slightly larger than stock, so you get slightly better fuel economy due to the "higher" final gear.) And this was on a 165k mile motor.
New engine is running richer than I'd like, but I can't get the Vf signal to produce 2.5v, only 3.4v.... Not sure why. Also have been getting terrible fuel mileage, but I'm into the boost all the time, so one tank in about 180 miles is not bad right? LOL