Detonation and/or pre-ignition kills the motors.
Tuning is the key as noted by many.
Stronger forged stuff just gives you a wider margin for error, and can hold up to higher ultimate power levels when your state of tune is correct. (But will fail just as easy if your tune is wrong at those higher levels of power.)
Last night, a local stock block 7MGTE failed at the track. He has a larger T4 on a log manifold, external WG, and the 550/Lexus combo. Spiked boost to 23psi, and boom went his motor. I'm not sure what gas he was running, but he talked about getting some 100 octane before the race, so I'm assuming he had that in there.
AF's were 11.8:1. He's not sure why it died, but now is blowing oil out the tail pipe bigtime.
My guess is the stock pistons failed, a ring land is either broken or melted, and possibly a top ring cracked or missing. (Think out the exhaust at high speed, into a spinning turbo... Ouch.)
I fried a #6 piston ring land at about 28psi of boost, also at AF's in the 11's. Simple formula appears here.
Too much boost, not enough fuel, and too much spark advance on stock pistons and they die. I'm starting to think AF's in the 10 or richer range for high boost is a good idea. Also pulling 5 degrees of advance from your base setup so it's not there at high boost is a good idea too. (I can add it back with the Emanage everywhere the engine is not under pressure.)
So, in response to your question about the engine being strong. Sure it's stronger than most, but nothing is "bulletproof".
BTW, I've had a crank twisted. Fully built stroker motor, was not hooked up right, and the guy at the shop took it out for a ride. (No boost controller hooked up, no fuel pressure regulator hooked up.) He tells me "your car is damn fast, runs like a raped ape." I start the car, and it's knocking already, shop says that's piston slap... Also the state of tune is totally wrong. TPS is out of adjustment, most of my gauges don't work. Boost spikes past 20. After 4 hours of chasing down problems, I get it to hold steady boost at 20, but 350 miles later, it dies of a twisted crank, and the subsuqent wiped out bearings. 2100.00 later, the motor is running again. (New block this time with 4k clearance on the pistons v/s the 6k that ROSS says is right.) Shop is not allowed to test drive the car, and the guy who did, is no longer at that shop.
If your going for ultimate power, be carefull, or be prepared to spend.