I never had a problem with my security system... BUT, I did have a fusible link go out for the charging system once, and when that goes you can no longer turn the engine over... or even get your radio to turn on, or just about anything else for that matter.
Lets just put it simply - that was one hell of a long night when that went out - It was about 2 in the morning driving home on the interstate - saw the battery light and the e-brake light come on and my radio kept turning on and off and I was just like wtf noooooo.... so yeah, I tried to sleep in my car that night at a gas station that I just barely made it to... and I couldn't sleep, so once daylight came along I could actually figure out what the problem was - then I got the fuse, installed it, and went on my way...
So yeah - it can be smaller problems like that as well at times.