I use super antispyware, but only if I am doing a full scan. Its free, so its useful for covering the virus side. I usually run 5 at once to get my scans out of the way for that week. only takes 2 hours or so. I run spybot, avg antivirus, avg antispyware, super antispyware, and one other (cant remember) and it keeps my system clean. if one misses something, the other usually picks it up. They each have different detection methods and some viruses go inactive if they see a scan so you cant find them. For those I use blacklight and hijackthis since they use a passive method and give you a list of what processes are running. Nothing escapes those that i've seen so far, except for a bios virus that caused a client's laptop to become a midi player and never get past the bios. It would just play 16-bit songs like the Mario theme. It was hilarious! Minus the over-writing of the bios.