Can it be done, yes with the proper amount of tuning. But it could be done better with a standalone.
All piggy backs do is modify the signal being sent to the ECU, in effect lying to it. But you are still running on the stock ECU, and it's pre-programmed fuel and timing maps.
Even if you alter the inputs you still have to follow these maps and there limitations. The fact that Will got 730hp out of the ECU on piggy back is a testament to it's flexibility and power. However it is still limited, like stated before by fuel and timing maps.
We use the fuel maps beyond what Toyota designed them for by increasing injector size and unmetered air flow, or modifying the air flow readings. We have done a pretty good job of this, and it's pretty refined by now. Now we run in to the next limitation, timing maps. Ideal timing is critical for big power. The more boost you run the more timing advance you need. The problem is Toyota only programmed the ECU for timing advance up to about 12 psi and from there it goes no further. You can play with this by adjusting base timing, running a higher octane, running a richer mixture. But all these detract from the maximum amount of power you can make.
This is the reason full standalone systems were made. So you can tailor fit the maps to your needs, allowing more control over the engine to run ideal conditions at all times. The stock ECU no matter how many piggy backs you put on it will never be able to do this. You can run the engine to big power on the stock ECU, but it will never be as good as a standalone.
Even Will Neely will admit he could have made more power with the same mods if he had gone stand alone.
Also, the stock ECU, and a stand alone are pure systems. The ECU communicates directly to the engine. No translator or signal modifiers, the signal is clean and pure, not dirtied or slowed down. Another problem with piggybacks is that they create additional failure points. When it’s just the stock ECU or piggyback it’s only one piece of electronic you have to worry about. Is it set right? Is it doing its job? When you start introducing failure points you have to start relying on each point in the chain. Is it doing its job? Is it sending the right information to the next electronic on the chain?
So basically what I’m saying is that yes, the ECU can be used to achieve big numbers. But a stand alone system will do it me efficiently, more reliably, and safer. In the end the money you spent on piggy backs and the hard ware to achieve high horse power could have been better spent on a stand alone system to make even bigger numbers.