I'll just add a data point here.....
I'm running the Boss Jr. 57 Trim turbo with a Lexus AFM, MKIV FP, AFPR and 550 cc/min injectors (with lots of other mods that don't really impact this discussion). I had previously been running a VPC/S-AFR setup on a SP63 turbo.
On the new setup, I originally had the S-AFR installed as well. With everything set at 0 on the S-AFR, I dialed in the fuel pressure to achieve a Vf of 2.5V. That's it. I did not adjust the original screw in the Lexus AFM.
I've been driving the car for a few weeks now, and during all closed loop conditions, I'm at a Vf of 2.5. In open loop, AFRs stay very close to 11.5 throughout the powerband. I bypassed the S-AFR, one less thing to go wrong. I may have gotten lucky, but it worked out very well and the car idles and drives like it rolled off the showroom.
That said, I also have an HKS injection pulse monitor and I am approaching ~85% duty cycle at just over 1 bar. I'll hit fuel cut just above that, obviously for good reason.