Possible, sure. But the problem is that a drilled hole is not exactly a precision upgrade. In order to be sure that it's a good thing, you'd want to get the injectors flow matched, and then you might as well just spend the money on good ones in the first place. Widely varying flows from different injectors mean that the A:F ratios in the individual cylinders is different, and while the ECU thinks that it's okay (Because it's okay ON AVERAGE) one or more cylinders may in fact be running dangerously lean. Kaboom.
The only way that I could see this making any kind of sense at all is with a throttle body injection system, where there isn't so much requirement for matching different injectors.