I've always thought it more prudent to spend money on a standalone and a sufficient fuel system than to rely on forged internals to not melt or explode.
In other words, building up a beefy engine then pushing like mad on the stock ECU with piggybacks does work, but also leads to plenty of blown motors. I figure if you can push an original block to 300hp (presumed the maximum available from the stock ECU at elevated boost, aka "fuel cut"), you could push that same block to 500hp or higher with a rock solid tune on a good stand alone system, with the right knowledge, research, fuel, and care. The guts of the motor are sufficiently strong to deal with the stress... it's everything else that appears to cause the guts to fail; heat, detonation, ect.
On the bright side, should you run a stock block and standalone, and gods forbid the stock block blows up, you'll already be set for engine control and fuel... just need to rebuild the motor