Few things to consider about that "test".
1) They used SUV's. They are large bricks anyway, so generally there is tons of areodynamic drag to deal with on a SUV with or without the windows up or down. (It does increase as the windows go down, and the speed goes up, but they are square edged bricks with huge frontal areas to start with.)
2) They use large V8 engines that burn more fuel per revolution than our somewhat smaller 3.0 I6. All things being equal, at some point large displacement engines start to return a very similar fuel economy. Case in point. Chevy truck with a 454 gas engine. Get's 12 mpg on a good day, no head wind and empty. Load it up with camping gear, tow a few ATV's on a trailer and run it up into 20mph headwind? Guess what? Get's about 12mpg...
The amount of power needed by the vehicle to maintain speed is less than the amount of power being produced by the engine by a larger margin, so empty or fully loaded, that vehicle just gives you 12mpg either way. (And I'm guessing so did the SUV's used on Mythbusters.)
Ok, back on point. The only way to do this test would be to use the same vehicle on the same day driven on the same road under the same conditions. You don't have to run them out of gas. You just need a fuel container that has a clear sight tube.
Start with exactly the same amount of fuel. (Easy to do since you can see the fuel level in the sight tube.)
Drive the car down the road the same distance, then turn around and drive back. Measure the fuel level.
Fill it back up to the starting point, and repeat the test.
That would have been accurate.
Running two Stupid User Vehicles and changing drivers is not accurate. The engine's tune, state of fuel injectors, 02 sensor and so many other variables can affect the mileage quite a bit. Just going from one engine to the other would affect gas mileage. Were both SUV's the same mileage? If one engine was built better than the other, or had more or less wear than the other it will affect fuel mileage, possibly more than using the AC or not.
AC compressor pumps use quite a small amount of power. A few HP at most. At highway speeds, your vehicle needs a few HP to overcome the resistance of the air, and the grade of the road. (And all the other factors that add up like tire rolling resistance etc.)
I'm sure some math wiz could figure it out and give us the figures, but I still think basing your idea that AC sucks more gas than open windows is pretty dang silly. (Besides the fact that those of us with working AC are cooly driving around while your sweating and stinking up your car... )