Actually, no, it's not *all* in the tune. That's only half of the equation.
The tune will affect premature failure due to two things - combustion temps too high, causing melted or burned pistons, and detonation, causing smashed or cracked pistons.
The piston design will affect longevity as well, but due to different factors. Quench, ring design and placement, and several other factors. Piston design failures could cause the block to wear unevenly, the face of the piston to burn due to hot spots during combustion, etc.
I'm not saying that the Probe design is bad. That's a call to be made by others with more knowledge than I. What I *am* saying is that they are an unknown. Until there are several examples of 500hp engines, built properly and run hard for years, then torn down and the results posted, they will continue to be unknown. This kind of feedback is unlikely to appear soon, for a number of reasons. The number of 500hp builds just isn't that high. The number of 500hp builds that are finished is even smaller. The number of 500hp builds that are finished and run for at least a few years, without getting parted out or wrapped around a pole, then are torn down to check how the internals are holding up... well, I suspect you'll be able to count those using just your thumbs, if you're willing to wait another couple years.