it depends. for example im running the 2jz tb. changes that were needed ->
throttle opens opposite stock, you need a new tps to compensate or swap the throttle plate around. i got lucky and was able to get the 2jz tb to work with the stock electronics.
the stock flange is 63-65mm and drilled to fit the stock tb. you will need an adaptor.
the throttle linkage will need to be changed.
your question is a little open ended so if you had one in mind specifically we might be able to offer better info